ImplantSafe DR

Around 50% of implant patients will develop peri-implant mucositis over time. Approximately one-third of all patients will develop clinically manifested peri-implantitis.

ImplantSafe DR identifies these patients at an early stage, supports communication in dental hygiene, and helps ensure maximum compliance with the necessary recall intervals. In this way, long-term implant success can be guaranteed, forensic risks reduced and delegated preventive measures increased.

Early Detection of Active Collagen Reduction with aMMP-8

The Test System – ImplantSafe DR

Most periodontal and peri-implant diseases develop insidiously. It may take decades for clinically manifest periodontitis or peri-implantitis to be diagnosed. That’s because, until now, the focus has been on determining the extent of the degeneration (probing depth and COP), rather than on detecting the start of collagen breakdown in the periodontal tissue.

New Definition of Peri-Implantitis 2018: What’s Healthy and What’s Not?
With the introduction of a new, global classification system for periodontitis on 21 June 2018, peri-implantitis was also redefined. According to this classification, peri-implantitis is characterized by inflammations in the peri-implant connective tissue, as well as progressive loss of the supporting bone. Peri-implantitis may begin at an early stage of the implant aftercare process. The disease progresses in a non-linear fashion and at a fast pace. Sites of peri-implantitis show clinical signs of inflammation and increased probing depths compared with initial measurements.

However, it is not possible to distinguish healthy from unhealthy peri-implant tissue using probing or pocket-depth measurement alone.6 If patients with progressive collagen reduction can be detected in a reliable way and at an early stage of the disease, this presents us with a huge opportunity to reduce the prevalence of peri-implantitis.

Quantitative Measurement of Progression
The aMMP-8 technology used in the ImplantSafe Digital Reader System is two to three times more sensitive than the standard “bleeding on probing” (BOP) procedure, enabling a more reliable quantitative assessment of periodontal “grading” – a key progression parameter.

Monitoring Collagen Breakdown for Long-Term Success

Subclinical Collagen Breakdown – the Risk for Implants

With the rising number of implants, an increase in the number of implants lost and of complications due to hidden tissue breakdown is to be expected despite the high rates of implant success.

Dental Implants – a Success Story
Dental implants are a success story. They give patients a new lease of life, more confidence and a stronger bite. It’s not surprising, then, that increasing numbers of patients are choosing implant-supported tooth replacement despite private costs of around EUR 1,250 to 3,000 per implant. The German Association of Oral Implantology (DGI) estimates that, in Germany alone, the number of implants inserted each year has risen yearly to reach over 1 million at present.

Peri-Implantitis is Gaining Ground
Around 87% of younger senior citizens say they are satisfied or very satisfied with their implants.2 However, despite significant success rates, one implant is lost every four minutes, which translates into 140,000 cases each year.

Undetected inflammation and tissue breakdown processes are among the most frequent causes of implant loss. On average, peri-implant mucositis is detected in around 47% of implant patients and almost 30% of implants. A recent meta-analysis indicated that peri-implantitis was found in almost 20% of implant patients and around 9% of implants. The best protection against peri-implantitis is early detection of collagen tissue breakdown around the implant.

Early Detection – the Best Protection
The earlier a hidden inflammation can be detected, the easier it will be to treat. What’s more, the earlier the affected areas of the implant and periodontium are specifically and professionally treated, the higher the chances that the patient will make a full recovery.




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ImplantSafe DR Diagnostic Test Can Help with the Long-Term Preservation of Implants

Early Detection & Prevention Increase the Sustainability of Implant Care

Especially in cases where implants are placed following periodontal tooth loss, it is essential that the patient collaborates in the subsequent implant aftercare program but also in the patient and recall management system operated by the dental clinic.

Diagnostic enhancement with the aMMP-8 test
An early diagnosis of initial-stage, possibly not yet visible, collagen breakdown processes can be critical to long-term implant preservation. That’s because with early detection of acute inflammatory processes, preventive measures can be taken in time to prevent progressive tissue degradation. Bleeding on probing (BOP) and x-ray results may come too late. After all, these only serve to reveal that existing, in some cases irreversible, damage has already been done to the peri-implant tissue.

The aMMP-8 test offers a diagnostic enhancement option that delivers results after breakdown processes have begun but before measurable tissue or bone loss can be detected. Which means that, if the test result is positive, early intervention can be provided in the formed of the required treatment.

Increase Recall Compliance & Improve Sustainability – Prevent Tooth Loss

The Personalized Prevention Plan for Implant Protection

Almost half of all adults in Germany are diagnosed with moderate periodontitis (grade 3) (DMS-V). Experts estimate that around 28 million German adults are in need of periodontal treatment. And yet only around one million treatments for periodontal disease were claimed from statutory health insurance companies in 2016.

In other words, only 3 to 4% of those affected are receiving suitable treatment. This discrepancy may possibly be explained by the fact that the early stage of periodontal degradation is not be detected in time or that the necessary treatment is not pursued.

As peri-implant inflammation processes are usually painless, patients frequently underestimate the potential health risk they present. As a result, they generally lack awareness of the problem and often experience progressive inflammation over many years. The personalized prevention plan helps inform patients, saves time, and improves compliance.

Patient Information Sheet
The patient information sheet explains to patience the importance of taking appropriate preventive action to counteract active oral collagen breakdown processes (silent inflammation) effectively and as early as possible in their development.

Personalized Prevention Plan
Once the analysis has been performed, you can print out the result immediately and incorporate it into the personalized prevention plan in the form of a label. You can mark the risk level of the individual patient on an informative traffic-light chart. The patient is then fully informed about his/her personalized prevention plan and tailored dental hygiene program to minimize as far as possible the risk of oral tissue loss around the implant. Your personal recommendations for prevention or treatment and for optimizing care of implants at home can also be documented.

Patient Consent
By signing the Consent form, the patient consents to any interdisciplinary communication with the specialists providing his/her care that may be necessary. The patient information sheet supports risk disclosure to the patient and serves as documentation of the advice provided by the clinic.

SST DR Site-Specific Test

ImplantSafe DR

TypeQualitative/quantitative* aMMP-8 immunoassay
Patient SelectionThe SST test is used for screening & monitoring of PA and PI patients
Field of applicationInitial early diagnosis and monitoring of PA and PI patients
GoalIdentification of patients with both incipient and advanced oral
Silent inflammatory or subclinical collagen degradation
What is measured?aMMP-8 concentration in PISF or GCF
SamplingSecretion from gingival pockets (sulcus fluid)
Duration of the practice sample collection
(hands-on phase)
approx. 2 min & 5 min elution
Duration of the automatic
5 Min.
ResultSingle tooth or implant measurement in ng/ml from 20 ng/ml
User groupZA & DH
PSI Category0–4
TypeScreening & Monitoring
Advantagesespecially suitable for dental diagnostics and can support any PZR or GOZ No. 0010 as immunological preventive diagnostics
suitable for the identification of incipient degradation processes on implants
ideal monitoring method for the identification of responders and non-responders
Useful supplement to document treatment progress
Notes and restrictionsImplantology No indications
Periodontology No indications

Become a PerioPrevention Center and Receive your Quality Seal

The PPC quality seal (Perio Prevention & Oral Anti-Aging Center) is the mark of quality for dental clinics that specially focus on prevention and are certified in the area of immunological diagnostic technology.

More than 300 PPCs across Europe use the latest saliva diagnostic technology to guarantee the best possible preservation of natural teeth, protection of implants, and maintenance of general health.